CoA. 2.2. These solutions were mixed to form one equimolar solution (33.3 mM each). In silymarin+ sodium arsenite group, silymarin could significantly (p<0.001) reverse the adverse effect of sodium arsenite on sperm viability compared to sodium arsenite group (Figure 1). NFPA 704. data unavailable. To prepare arsenate and arsenite solutions, sodium arsenate (Na 2 HAsO 4.7H 2 O) and sodium arsenite (NaAsO 2) (Aldrich and Merck Co., respectively) were dissolved in distilled water in concentration of 1 000 mg/l. Sodium Arsenite Normality Solutions are most commonly used to test other products – often in titrations. Formula: NaAsO2 Formula weight: 129.91 UN Number: UN1686 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code: 2841.90 Hazard Statements: H301-H331 Toxic if swallowed. Packaging 100 g in glass bottle Sodium arsenite can be used as a reducing agent in organic chemistry, as it is able to reduce a trihaloalkane to a dihaloalkane: CHBr 3 + Na 3 AsO 3 + NaOH → CH 2 Br 2 + Na 3 AsO 4 + NaBr Safety SODIUM ARSENITE CTHH: NaAsO2 CAS No. Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL). According to the design of this study, HaCaT cells were treated with 0.00, 0.05, 0.10, and 0.25 μM NaAsO 2 for 24, 48, and 72 hours (h). Sodium arsenite solution MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS; CoA; CAS #: 7784-46-5 Grade: Reag. Although EPA has received 1,714 nominations during this period, only 871 unique technologies are represented here because sponsors may nominate a technology more than once. Twenty of the isolated arsenic-binding proteins were further peptide-mapped by … Then in the presence of a control group the cells were exposed to 1, 10, 25, 50, 75 and 100 nM of sodium arsenite (Merck Company, Germany). Prepare the sodium arsenite solution by dissolving 5 g of sodium arsenite and 5 g of sodium citrate tribasic in 100 mL H 2 O, add 5 mL of glacial acetic acid, mix, and adjust to 250 mL with H 2 O. * Sodium Arsenite can cause poor appetite, a metallic or garlic taste, stomach pain, nausea, vomiting and headache. Molecular Weight: 129.91. USP. Cacodylic acid is a natural product found in Codium fragile and Sargassum lacerifolium with data available. Full PDF Package Download Full PDF Package. Cell growth and labelling Correspondence to C. Rodrigues-Pousada, Laboratorio de Geniitica Molecular, Instituto Gulbenkian de Cikncia, Rua da Quinta Cultures of T. pyriformis (CGL strain) were grown Grande - Ap. d-Mannitol, dimethyl sulfoxide, hydrogen peroxide and sodium arsenite were from Merck (Darmstadt, Germany). Female Balb/c mice ( n = 15) were exposed to 0, 12, and 20 ppm of NaAsO 2 in drinking water from 8th to 18th day of gestation. Research. 37 Full PDFs related to this paper. Using a strain of rat that occasionally showed spontaneous enlargement of the duct, Byron et al. SODIUM ARSENITE. The model of L-02 liver injury induced by different concentrations of sodium arsenite (NaAsO 2) was established. 106277. Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. Sodium arsenite is an appropriate chemical stressor to induce the production of heat shock proteins, and the formation of cytoplasmic stress granules. The lethal oral dose of sodium arsenite in most species is 1–25 mg/kg. Part XIII. HACH US CAREERS CLAROS 800-227-4224. USP Less<<. Product No. Arsenate is salt or ester of arsenic acid having a negative ion of AsO 4 3-, arsenite is a salt or ester of arsenious acid having a negative ion of AsO 4 3-derived from aqueous solutions of As 4 O 6 and arsenide is a negative, trivalent binary arsenic compound such as H 3 As or GaAs. Also called sodium meta -arsenite, it is the sodium salt of arsenous acid. Sodium ortho -arsenite is Na 3 AsO 3. The compounds are colourless solids. A mixture of sodium meta -arsenite and sodium ortho -arsenite is produced by treating arsenic trioxide with sodium carbonate or sodium hydroxide. Material Safety Data Sheet or SDS for Sodium arsenite solution 106277 from Merck for download or viewing in the browser. The Lethal Dose 50 (LD 50) of oral sodium arsenite in rats was 41 mg/kg. Fourteen days after dosing with gallium arsenide, 90.7% + or - 35.4% of the arsenic and 99.4% + or - 38.7% of the gallium was eliminated in the feces in the 1,000 mg/kg group. Colchicine (∼95% pure, HPLC grade), sodium arsenite and Giemsa stain were purchased from Sigma Aldrich Chemical Co. (St Louis, MO). Spermatozoa treated with silymarin (20 μM, Sigma, USA) + sodium arsenite (10 μM) and 5. Molecular Weight: 129.91. Used as an antiseptic, in insecticides and herbicides, to preserve hides and in making dyes. Spermatozoa treated with silymarin (20 μM, Sigma, USA) + sodium arsenite (10 μM) and 5. groups: control, sodium arsenite (5 mg/kg), curcumin (100 mg/kg) and curcumin+sodium ... Merck, Germany) was mixed to 20 µL sperm suspension. To evaluate α-amylase activity, barley seeds were sterilized in 15 % sodium hypochlorite for 1 min, then washed several times with distilled water. Molecular Formula: Na•AsO 2. Effect of sodium arsenite on the number ofmitotic cells. A short summary of this paper. After … Test Chemicals. Sodium arsenite (A. none. The Merck Veterinary Manual was first published in 1955 as a service to the community. This Paper. 補足情報: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges. Clonality. arsenite (NaAsOJ was obtained from Merck (ref. All other chemicals were procured from Sigma Aldrich (USA). 49 232 91; Sodium arsenite, liquid (solution) Sodium arsenite, aqueous solution appears as an aqueous solution of a solid. Toxic by ingestion, inhalation or skin absorption. Used as an antiseptic, in insecticides and herbicides, to preserve hides and in making dyes. WHITE OR GREY HYGROSCOPIC POWDER. White or grayish-white powder 2000; Sultana et al. 0; and 50 fiM) and colcemid 0.1 f^g/m[ were added simultaneously to the cultures. Arsenite removal from water by electro-coagulation on zinc–zinc and copper–copper electrodes. A short summary of this paper. The solutions were prepared daily. USP. Sodium arsenate dibasic heptahydrate (As(V)) is an arsenic compound. Toxic if inhaled. There are some existing reports in which arsenite intoxication is associated with spermatotoxicity [87–89], inhibition of testicular androgenesis, and reduction of the weight of the testes and … Merck 109950.0001 | Sodium thiosulfate solution for 1000ml 0.1 mol/l (0.1N) Titrisol 258,17 TL Merck 106448.1000 | tri-Sodium citrate dihydrate for analysis 1KG CAS Number: 7784-46-5. The aim of this study was to analyze the effect of sodium arsenite (NaAsO 2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. cryst.,) in oxygen has been measured in a rotating-bomb calorimeter charged with an aqueous solution of sodium hydroxide, when the products of combustion are sodium arsenite and sodium arsenate, in aqueous solution.Incorporating data for the heat of reduction of sodium arsenate to sodium arsenite and the heat of solution of … Form liquid. LOTUS - the natural products occurrence database. CoA. The 96-well plates with the assay mixtures were covered with a lid and incubated at 30°C in a rotary shaker (700 r.p.m.) Spermatozoa treated with sodium arsenite (10 μM, Merck, Germany), 4. Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges. Sodium arsenite solution MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Prepare solution A by mixing 0.3 g of ascorbic acid in 10 mL of ice-cold 0.5 M HCl. Emergency Life-Support Procedures: Acute exposure to sodium arsenite may require decontamination and life support for the victims. Order Status Contact Us Login. Select Language. View all Active Pharmaceutical Ingredients (API) with APIs manufactured or supplied by Merck Group on PharmaCompass.com. Treating human embryonic kidney cells (HEK293) with sodium arsenite reduces cell viability in a dose- and time-dependent manner. The rats were divided randomly into different groups, each containing 5 animals. Sodium arsenite (SA, NaAsO 2, dissolved in normal saline) and other chemicals were of analytical grade and purchased from Merck Company (Darmstadt, Germany). Compare. Catalog Number 106277. Lower dietary levels produced a lower incidence of enlargement. distilled water, sodium arsenite (8 mg/kg/day, Merck, Germany), Vit.E (100 mg/kg/day, Sigma, USA) and sodium arsenite +Vit.E. 5. The reagents were orally given to the rats by gavage for 8 weeks “as the duration of spermatogenesis in wistar rats is … Physiological saline was given to the first group. In the scope of the study, the protective effect of hesperidin (HES), a flavanone glycoside, was investigated against sodium arsenite (NaAsO2, SA) induced heart and brain toxicity. iAs III (sodium arsenite, Art. Prices are subject to change without notice. New Customer? CAMEO Chemicals. Animals were housed and fed as previously described . Express Order. Product Name Sodium arsenite solution. The heat of combustion of arsenic (α, rhomb. Traceability NIST SRM. Cart 0 / Quote 0. Arsenic tribromide, arsenious and arsenic oxides, and aqueous solutions of sodium arsenite and sodium arsenate Melting point 195-196°C. By Fábio Henrique Fernandes. Login. The doses of SA and GA were chosen on the basis of previous studies (Mansouri et al., 2013a ; Kadirvel et al., 2007 ; Rodrıguez et al., 2001 ). Sodium arsenite, 0.1N Standardized Solution. Four-month male Wistar albino rats, weighting 180–200 g, were got from the animal house, Faculty of Pharmacy, King Saud University. Toxic if inhaled. … This table contains information on each unique technology nominated for the Presidential Green Chemistry Challenge from 1996 through 2016. Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARγ pathway against oxidative injury in mice hippocampus ... membrane (Merck Millipore, 0.2 μm, ISEQ00010). Purity: ≥90%. 37 Full PDFs related to … iAs III (sodium arsenite, Art. The effect of sodium arsenite on the male reproductive system is poorly defined. アプリケーション： Sodium (meta)arsenite is a poison which induces oxidative DNA damage. In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group. Methanol gradient grade for liquid chromatography LiChrosolv Reag. Jyotirmoy Ghosh, Parames C. Sil, in Handbook of Arsenic Toxicology, 2015. Sodium arsenite (E-Merck, Germany) was used for study. Toxic to aquatic life with long lasting effects. The concentra-tions were prepared in such a way that the de-sired quantity of arsenite was contained in 0.5 ml of solution. Sodium arsenite, 0.1N Standardized Solution. 2012). By Life Science Archives LSA. 6287). The management of arsenic intoxication among the affected people is a mammoth challenge. Sodium bicarbonate (GR), concentrated HCl, nitric acid (minimum 69% GR), sulfuric acid, glacial acetic acid, methanol and potassium chloride (AR) were obtained from E.Merck (India) Ltd. 5. For Research Use Only. Based on the solvents, we chose two control groups, distilled water and DMSO. To better characterize the interaction of protein–cysteines with sodium arsenite, arsenic-binding proteins were identified from the arsenic-resistant Chinese hamster ovary cell line SA7 using a p-aminophenylarsine oxide (PAO)-agarose matrix in combination with proteomic techniques. Sodium Arsenite: Show More Show Less: Safety and Handling GHS H Statement Fatal if swallowed or in contact with skin. Induction of DNA strand breaks and oxidative DNA base modifications by arsenite after a short time ( A) and 18 h ( B) incubation of HeLa S3 cells.Logarithmically growing cells were treated with arsenite for 0.5, 1, 3 or 18 h, respectively, and the frequencies of DNA strand breaks and Fpg-sensitive sites were determined by alkaline unwinding as described in the Materials … Country of Origin: Made in India. General Description. Sodium arsenate is the inorganic compound with the formula Na 3 AsO 4. The As compounds used in these experiments were sodium arsenate (Na 2 HAsO 4 7H 2 O, Merck) and sodium arsenite (NaAsO 2, Merck). From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. Inorganic arsenic (iAs) exposure induces a decrease in glucose type 4 transporter (GLUT4) expression on the adipocyte membrane, which may be related to premature births and low birth weight infants in women exposed to iAs at reproductive age. 2 4 Hours of treatment Fig. Arsine gas poisoning generally occurs in the industrial setting, where its production arises from the action of acid or water on arsenic-bearing metals. Despite arsenic being a severe health hazard, a safe and effective remedy against arsenic poisoning remains elusive. Metabolites Approximately 6 g of each of the soil samples were enriched in 60 mL of minimal salt medium (MSM) containing 2 mM of sodium arsenite, NaAsO 2 (Merck, Germany) for recovery of chemolithoautotrophic As(III) oxidizing bacteria (Santini et al. 2013. sodium arsenite in 50 mM morpholineethanesulfonic acid (MES), pH 6.0, at The MIC, defined as the As(III) concentration that inhibited confluent growth 25°C. Animals. Sodium arsenite, administered to mice at a 53.39 μmol/L for 365 days, caused a decrease in sperm count and motility and an increase in abnormal sperm. Application: Sodium (meta)arsenite is a poison which induces oxidative DNA damage. Production. Spermatozoa treated with silymarin (20 μM). DNA histograms of CHO cells. Toxicologic …, 2004. Imran Ali. Download Download PDF. Sodium arsenite did not affect the morphology and diameter of spermatogonial nucleus (p>0.05). 8.4.4 Testicular Toxicity. Full PDF Package Download Full PDF Package. Then, 1 μL of this mixture was added to 2 mL of SB (50 μM) and its emission profile was recorded. It is usually handled as the dodecahydrate Na 3 AsO 4. Application Sodium arsenate dibasic heptahydrate may be used as a reference standard for the quantification of arsenic compounds in rice- and seafood-based samples by ion chromatography-inductively coupled plasma/ mass spectrometry. CAS #: 7784-46-5 Grade: Reag. (10% in distilled water, Merck, Germany). Animals were housed and fed as previously described [] . The effect of sodium arsenite on the male reproductive system is poorly defined. The solutions were prepared daily. Sodium Arsenite AR. Product name : Sodium Arsenate CAS-No. CAS 등록번호: 7784-46-5. Next, the Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Purity: ≥90%. Ph Eur, 2,5 L, orderable only in packs of 4 . 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 Sodium arsenite solution MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. CAS #: 7784-46-5 Grade: Reag. USP Reag. USP An invalid quantity was specified. View Pricing & Availability. The percentage of sperm viability in sodium arsenite group was significantly decreasedin comparision with control group (spermatozoa at 180 min) (p<0.01). However, the relationship between p38 and Bim(EL) in this apoptosis has not been fully defined. Sodium arsenite suppresses the expression of uterine estrogen receptor-α at both proteomic and genomic levels via limiting the functions of the cell cycle regulating proteins CDK4 and cyclin D1 at G1 phase [, ]. Inorganic arsenicals, including sodium arsenate and lead or copper arsenite; organic arsenicals, such as carbarsone and tryparsamide; and arsine gas are the major toxicologic forms of arsenic. After … Merck Millipore Chemicals: volume / package size: 1 l: chemical: sodium arsenite: T. Also Purchased. 추가 정보: This is classified as a Dangerous Good for transport and may be subject to … Metabolites Chronic Health Effects The following chronic (long-term) health effects can occur at some time after exposure to Sodium Arsenite and can last for months or years: Cancer Hazard * Sodium Arsenite is a CARCINOGEN in humans. Four-month male Wistar albino rats, weight-ing g, were got from the animal house, Faculty of Pharmacy, King Saud University. Safety Data Sheet for Sodium arsenite solution 106277. Development. Synonym (s): Monoclonal Anti-Neural enolase, Monoclonal Anti-2-phospho-D-glycerate hydro-lyase, Monoclonal Anti-Neuron-Specific Enolase (NSE) antibody produced in mouse, Monoclonal Anti-gamma-enolase, Monoclonal Anti-2-phospho-D-glycerate hydrolyase, Monoclonal Anti-Enolase 2 (gamma, neuronal), Monoclonal Anti-NSE. GHS P Statement Obtain special instructions before use. CAS 番号: 7784-46-5. Read "Induction of HSP72 by Sodium Arsenite Fails to Protect Against Cholecystokinin–Octapeptide-Induced Acute Pancreatitis in Rats, Digestive Diseases and Sciences" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Sodium arsenite had no effect on sperm DNA integrity and histon-protamine replacement (p>0.05). Sodium arsenite, aqueous solution appears as an aqueous solution of a solid. Toxic by ingestion, inhalation or skin absorption. Used as an antiseptic, in insecticides and herbicides, to preserve hides and in making dyes. The decline of cell viability is due to apoptotic death since arsenite treatment reduces Akt activity and the Bcl2 level but increases caspase 3 activity and the cytochrome c level. Chemsrc provides sodium arsenite(CAS#:7784-46-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. The concentration is determined by volumetric titration and refers to 20°C. The trisodium salt is a white or colourless solid that is highly toxic. sodium arsenite, providing an approximate structure of NaAsO2. SDS. Avantor ®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries.Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. 순도: ≥90%. Our high precision normality solutions provide NIST traceability, certification, readily available Certificates of Analysis, high purity components, and testing by degreed chemists. Divided into 5 different groups, distilled water and DMSO ( USA ), USA ) + sodium arsenite an! Merck, Germany ) we chose two control groups, 7 in each group subject! Sodium arsenate CAS-No, and 0.3 % was detected in the blood Fowler 's solution,,... Fowler 's solution, i.e., potassium arsenite is listed as being KAsO2: HAsO2 and the is. ) + sodium arsenite ( 10 μM ) and colcemid 0.1 f^g/m [ added. 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